Warm Antibody Autoimmune Hemolytic Anemia 

1) DIAGNOSE AIHA

 • Anemia: macrocytic > normocytic, ↑ reticulocytes

 • Hemolysis: ↓ haptoglobin ↑ indirect bilirubin, ↑ LDH

 • Anti-RBC autoantibodies: positive direct Coombs

 • IgG type ± C3d

 • Blood smear: Differential → schizocytes, Positive → spherocytosis

2) LOOK FOR a cause  → Systematic screening

3) TREAT AIHA

   1 - Glucocorticoids

   2 - Rituximab +++

   3 - Splenectomy

   4 - Immunosuppressive agents



By Dr. Clara Pouchelon



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