Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary

 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M 9:1

 • Clinical Manifestations: Malar rash, Photosensitivity, Alopecia, oral ulcers, Lupus nephritis, NPSLE - If present, are evocative of SLE versus DIL

 • Laboratory Manifestations: 

   - CRP: Usually normal (except with serositis)

   - Cytopenia: Common

 • Immunologic Workup: 

    - ANA > 

    - Anti-ENA - Positive in up to 30%

    - Anti-dsDNA - Positive in 60-80% of cases

    - Anti-histone - Positive in 60-80%

    - Low complement - 50-60%

    - pANCA anti-MPO - Negative

 • Prognosis: Minor to life-threatening

 • Treatment: Usual therapeutic management of SLE

 • Evolution: Chronic disease



Dr. Laurent ARNAUD @Lupusreference



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