Primary Biliary Cirrhosis - Diagnosis Algorithm

Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort

Signs: Jaundice, Xanthelasmata, Hepatomegaly

Associated history: Symptoms of associated autoimmune disease (e.g. dryness of the eyes and mouth, Raynaud's phenomenon, arthritis), Personal/family history of autoimmune disease, Persistent pruritus after pregnancy

Diagnose PBC if 2/3 criteria are met:

1. Elevated ALP

2. Positive AMA or specific ANAs (e.g. gp210/sp100)

3. Liver biopsy findings consistent with PBC



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