Eosinophilic Esophagitis (EoE) - Topical Corticosteroids
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Description

Eosinophilic Esophagitis (EoE) - Topical Corticosteroids

 • Liquid - Budesonide - 1 mg PO BID - Mix with sucralose or honey to increase viscosity (1mg of drug + 5 packets of sucralose)

 • Powder - Fluticasone 1 mg PO BID - Can use blister packets within fluticasone diskus

 • Inhaled - Fluticasone 880 mcg BID - Do not inhale, do not use spacer

General Considerations:

 - Considered off-label use, FDA approved steroid formulations for treatment of EOE are currently unavailable

 - Administering the second dose at bedtime increases esophageal exposure time

 - Avoid eating/drinking 30 minutes after use

 - Avoid rinsing mouth immediately following ingestion unless oral Candidiasis occurs

Long-Term Maintenance:

 - Limited data on optimal dosage, and side effects of long-term use

 - Consider periodic monitoring for adrenal insufficiency and bone density until more safety data is available



Gastroenterology Review @GIreview



#Eosinophilic #Esophagitis #EoE #Topical #Corticosteroids #management #pharmacology
Contributed by

Dr. Michael Chew
@mchew85
GrepMed Gastroenterology-Hepatology Editor, Academic Hospitalist UC Davis Medical Center Internal Medicine, Yale Gastroenterology Fellow '22
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