Multiple Myeloma Diagnosis and Management Summary

Clinical Signs:

 • hyperCalcemia 28% (bone demineralization)

 • Renal disease 48% (light chain cast nephropathy and hypercalcemia)

 • Anemia 78% (bone marrow replacement) - Usually normocytic but can be macrocytic

 • Bone pain 58% (osteolytic lesions and pathologic fx)

Diagnosis - Clonal bone marrow plasma cells >10% plus one of:

 • Anemia. Hgb < 10

 • Ca > 11

 • Creatinine > 2

 • >5mm osteolytic lesion

 • >60% plasma clonal cell in bone marrow

 • FLC ratio >100 if FLC value is also >100



CMC IM Residency @CMC_IM



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