Morphology and Descriptions of Fungal Infections with Hyphae or Pseudohyphae in Tissues
Yeasts with Pseudohyphae: 
 • Description: Small yeasts (3-5 microns In size) intermingled with pseudohyphae and hyphae
 • Consistent with Candida spp. however Aspergillus spp. and other hyaline fungi can be confused histologically
Non-pigmented (hyaline), septated hyphae:
 • Description: acute angle branching
 • Consistent with Aspergillus spp, Fusarium spp, Scedosporium spp, Trichoderma spp, paecilomyces spp and others. Mucorales genera can sometimes have this morphology
Non-pigmented (hyaline), Pauciseptate Hyphae:
 • Description: pauciseptate ribbon-like hyphae with right angle branching
 • Consistent with Mucorales genera; however Asperglllus spp. and other septated hyaline hyphae can sometimes have this
Pigmented Yeasts and Hyphae with Septations:
 • Description: pigmented irregular hyphae and yeast-like structures both with septations
 • Consistent with dematiaceous fungi including: Madurella spp, Fonsecaea spp, Cladophialophora spp, Exophiala spp, Curvularia spp, Bipolaris spp, and others

Dr. Sara Dong @swinndong

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