NINDS Diagnostic Criteria for Guillain Barre Syndrome ...

NINDS Diagnostic Criteria for Guillain Barre Syndrome 
Features Required for Guillain-Barré Syndrome:
 • Progressive muscle weakness of more than one limb
 • Areflexia or hyporeflexia
Features Supportive of Diagnosis:
 • Progression of weakness for 2-4 weeks
 • Symmetric involvement, Mild sensory symptoms or signs, Cranial nerve involvement, Recovery begins 2-4 weeks after nadir, Autonomic dysfunction, Absence of fever, Elevated CSF protein
Features Casting Doubt on Diagnosis:
 • Marked persistent asymmetry of weakness
 • Persistent bladder or bowel dysfunction, Severe bladder or bowel dysfunction at onset
 • >50 Leukocytes/mm3 in CSF, Presence of polymorphonuclear leukocytes in CSF
 • Sharp sensory level
 • Central nervous system signs except in Miller Fisher syndrome-Bickerstaff brainstem encephalitis spectrum disorders
Features That Rule out Diagnosis
 • History of hexacarbon abuse
 • Acute intermittent porphyria
 • Recent diphtheritic infection
 • Poliomyelitis, botulism, toxic neuropathy, functional paralysis

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Contributed by

Dr. Gerald Diaz
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: | Twitter:
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