Natural History of Syphilis
Primary - 2-6 weeks after ...
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Description

Natural History of Syphilis
Primary - 2-6 weeks after infection
 • Chancre, Regional lymphadenopathy
Early Latent ≤ 1 year after infection
 • Asymptomatic
Secondary - 1-2 months after primary syphilis 
 • Rash, Fever, Generalized lymphadenopathy, Mucosal lesions, Alopecia, Hepatitis, Nephritis
Late Latent - > 1 year after infection
 • Asymptomatic
Early Neurosyphilis → Late Neurosyphilis 
Tertiary Syphilis - 2-50 years after infection
 • Gummatous disease (15%); Cardiovascular syphilis (10%); Ocular syphilis; Otic syphilis; Meningovascular disease, meningomyelitis, general paresis, tabes dorsalis (5%)

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