Heparin - Unfractionated Heparin (UFH) vs Low-Molecular-Weight ...
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Description

Heparin - Unfractionated Heparin (UFH) vs Low-Molecular-Weight Heparin (LMWH)
UFH:
 • Advantages: 
    - Rapid onset and clearance
    - Anticoagulation effect easily monitored
    - Ok in renal failure
    - Can be rapidly reversed with protamine
 • Disadvantages: 
    - Frequent monitoring required
    - Heparin-induced thrombocytopenia
LMWH:
 • Advantages: 
    - Longer duration Of action when administered sub-Q (as compared to heparin)
    -  Lab monitoring Of anticoagulation effect is generally unnecessary
 • Disadvantages: 
    -  Relatively contraindicated in renal failure
    -  Unknown Optimal dosing in morbidly obese patients
    -  If monitoring is needed, it requires an anti-factor Xa level (which is less available than aPTT)
    -  Heparin-induced thrombocytopenia (mixed data on whether risk is equal to, or lower as compared to UFH)
    -  Less reliably reversed with protamine

Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedicalLectures/

#UFH #LMWH #Heparin #comparison #Unfractionated #pharmacology
Contributed by

Dr. Gerald Diaz
@GeraldMD
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG:  https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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