Fever - Pyrogen Pathophysiology
EXOGENOUS PYROGEN
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Description

Fever - Pyrogen Pathophysiology
EXOGENOUS PYROGEN
 • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins
 • Virus: Double stranded RNA
 • Fungi: Mannan and glucan components
ENDOGENOUS PYROGEN - Transport to brain vasculature via:
 • Active transport across blood-brain barrier
 • Passive transport through fenestrated capillaries in the circumventricular organs

#Fever #Pathophysiology
Contributed by

Dr. Ravi Singh K
@rav7ks
Academic Hospitalist and APD @SinaiBmoreIMRes, Clinical reasoning,Simulation and POCUS enthusiast - https://twitter.com/rav7ks
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