Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 • Kidneys: CKD, ESRD
 • CV/Resp/Heme: CHF, valves, COPD, ILD, OSA, pHTN, Anemia
 • Psych: Depression, anxiety, Conversion
"I am weak":
 • Myopathy: Drugs (statin, chemo), EtOH, Rhabdomyolysis, Critical illness, Infection
 • Neuro: UMN (stroke, tumor), LMN (Polyneuropathy, ALS), NMJ disorder (Myasthenia, LEMS, Drug/Toxin)
 • Inflammatory/Rheum: Myositis (dermato-, poly-, inclusion body-), PMR, RA, SLE, Vasculitis
OVERLAP: 
 • Thyroid ↑↓, Cortisol ↑↓, Malignancy, Infection

Dr. Anand Jagannath @AnandJag1

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