Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 - ANCA Associated Vasculitis
 - Anti-GBM Disease
 - Double Positive (ANCA + anti-GBM)
10%:
 - Low Complement Levels: SLE, Cryoglobulinemic, MCTD, Antiphospholipid Syndrome, Rheumatoid Vasculitis
 - Normal Complement Levels: Scleroderma Renal Crisis, IgA Vasculitis, Behcet's Disease, Inflammatory Myositis
MIMICS:
 - Infections: Hantavirus infection/other hemorrhagic fevers, Leptospirosis, Legionellosis, Malaria, Babesiosis, Disseminated S. aureus infection, ARDS with multiorgan failure
 - Cancer: Amyloidosis, differentiation syndrome in APL
 - Cardiac: heart failure, cardiac tumor, mitral valve disease, Malignant hypertension
 - MAHA: HUS, atypical HUS, TTP, DIC

Dr. Ann Marie Kumfer @AnnKumfer

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