Antiphospholipid Syndrome (APS)
APS is a rare autoimmune ...

Antiphospholipid Syndrome (APS)
APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies formed against phospholipids
 • Blood clots can form in arteries, veins, or microvasculature
Antiphospholipid antibodies (aPL):
 • Lupus anticoagulant (LA)
 • Anticardiolipin antibodies (aCL)
 • Anti-ß2 glycoprotein I antibodies (aß2-GPl)
The origin of these antibodies is unknown
Diagnosis of APS - Presence of at least:
 • 1 clinical event (confirmed venous, arterial, or small-vessel thrombosis)
 • 1 of the three aPLs measured on 2 or more occasions 12 weeks apart
For patients to be diagnosed with APS, presence of 1 clinical event and presence of one of the antibodies have to be present
Treatment (EULAR Guidelines):
 • Anticoagulation with warfarin is recommended; INR target 2-3
 • If patient has an arterial/venous event while on warfarin and INR target 2-3 was achieved; it's reasonable to increase INR target to 3-4
 • DOACs are currently not recommended in APS

Mirna Guirguis, PharmD @mirna_guirguis

#Antiphospholipid #Syndrome #APS #diagnosis #management #anticoagulation #guidelines
Contributed by

Dr. Gerald Diaz
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: | Twitter:
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