Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison
Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 • Malignant lymphoma that is typically of B-cell origin
 • Etiology: Immunosuppression (e.g., HIV), EBV infection, Autoimmune diseases
 • Clinical features:
   - Adenopathy (painless)-localized above the diaphragm,
   - Contiguous spread
   - Lymph nodes in upper portion of the body (the neck, underarms, or chest).
   - B symptoms
   - Pel-Ebstein fever
   - Alcohol-induced pain: Pain in involved lymph nodes
   - Pruritus: (focal or generalized)
 • Usually no hepatosplenomegaly (Rare but might occur if the spleen or liver are involved)
 • No leukemic phase
 • Reed Sternberg cell
 • Prognosis: Good
 • ABVD , BEACOPP

Non-Hodgkin's Lymphoma:
 • Epidemiology: Increases with age (peak > 50 years)
 • Etiology:
   - Infections (HIV, EN, HTLV-1, HCV, H. Pylori)
   - Autoimmune diseases (e.g., Hashimoto thyroiditis, rheumatic disease)
   - Chromosomal translocation
 • Types: Classification based on:
   - Cell type (B cell, T cells, natural killer (NK) cells)
   - Location (nodal or extranodal)
   - Tumor grade
 • Adenopathy + Extranodal (Multiple lymph node groups)
   - Lymph nodes throughout the body, but can also arise in normal organs
   - Noncontiguous spread
 • Clinical features:
   - Nodal disease: B symptoms, lymphadenopathy, mass, Hepatosplenomegaly, cytopenias(bleeding)
   - Extranodal disease: GI, neuro, cutaneous involvement

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