Gonococcal Infections (Gonorrhea) - CDC 2021 Treatment Guidelines

Recommended Regimen:

 • Uncomplicated infections of the cervix, urethra, and rectum: adults and adolescents <150 kg ceftriaxone 500 mg IM in a single dose

 • Uncomplicated infections of the pharynx: adults and adolescents <150 kg ceftriaxone 500 mg IM in a single dose

 • Pregnancy: ceftriaxone 500 mg IM in a single dose17

 • Conjunctivitis: ceftriaxone 1 gm IM in a single dose18

 • Disseminated gonococcal infections (DGI): ceftriaxone 1 gm IM or by IV every 24 hours

 • Uncomplicated gonococcal vulvovaginitis, cervicitis, urethritis, pharyngitis, or proctitis: infants and children ≤45 kg: ceftriaxone 25–50 mg/kg body weight by IV or IM in a single dose, not to exceed 250 mg IM

 • Uncomplicated gonococcal vulvovaginitis, cervicitis, urethritis, pharyngitis, or proctitis: children >45 kg: Treat with the regimen recommended for adults

 • Ocular prophylaxis in neonates: erythromycin (0.5%) ophthalmic ointment in each eye in a single application at birth

 • Ophthalmia in neonates and infants: ceftriaxone 25–50 mg/kg body weight by IV or IM in a single dose, not to exceed 250 mg



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