Cytomegalovirus (CMV) in HIV-AIDS Patients

Cytomegalovirus (CMV): double-stranded DNA virus, herpesvirus family.

CMV infection: virus isolation or detection in any body fluid or tissue specimen regardless of symptoms or signs.

Diagnosis: Quantitative PCR and CMV pp65 antigenemia test. For tissue-invasive CMV CMV, inclusions or positive specific immunohistochemistry on histopathology.

Suspect these CMV-related conditions in any patient with HIV and CD4 50 or less:

 • Neurologic: Encephalitis, Myelitis, Polyradiculopathy, Peripheral Neuropathy

 • Eye: Retinitis (Most common cause of blindness in AIDS)

 • Liver: Hepatitis, Portal vein thrombosis

 • Endocrine: Infectious Adrenalitis, Pancreatitis

 • Pulmonary: Pneumonitis (In association with PJP/TB)

 • Cardiovascular: Myocarditis, ↑Cardiovascular risk, DVT

 • Gastrointestinal: Esophagitis, Enteritis, Colitis



By @TheIDtrivia



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