Workup of Hypercalcemia - Differential Diagnosis Algorithm

High or Normal PTH:

 • Hyperparathyroidism: Parathyroid adenoma, Parathyroid hyperplasia, Parathyroid carcinoma, Lithium

 • Familial Hypocalciuric Hypercalcemia

Low PTH:

 • High PTHrP: Malignancy

 • Normal PTHrP: 

    - Low 25 VitD: Multiple Myeloma, Skeletal metastatic disease, Milk Alkali Syndrome, Immobilization, Drugs, Endocrine disorders, Paget's disease, Viral Syndromes

    - High 25 VitD: Vit D Intoxication

    - High 1, 25 VitD: Lymphoma, Granulomatous diseases, Idiopathic calcitriol induced hypercalcemia, Infantile idiopathic hypercalcemia



Dr. Aisha Shaikh @aishaikh



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