Hypocalcemia Workup - Differential Diagnosis Algorithm

 • Low Magnesium, High Magnesium - Functional Hypoparathyroidism

 • High Phosphate, Low PTH - Hypoparathyroidism: Autoimmune, Genetic, Post-surgical, Post-radiation, Infiltrative disorders, HIV

 • High Phosphate, High PTH - Pseudohypoparathyroidism, Vitamin D resistance, Vitamin D deficiency, CKD

 • Low Phosphate - Vitamin D deficiency

 • Drugs: Calcium Chelators, Lactate, Citrate, EDTA, Bisphosphonates, Denosumab, Cinacalcet, Cisplatin, Fluorouracil/Leucovorin, Phenytoin, Foscarnet, Fluoride poisoning

 • Extravascular deposition: Hyperphosphatemia, Acute Pancreatitis, Sepsis, Osteoblastic metastases, Hungry bone syndrome



Dr. Aisha Shaikh @aishaikh



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