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Diuretics - Pharmacology Thiazides diuretics: • Inhibit Na+ Cl- cotransporter in distal tubule • Chlorothiazide, Chlorthalidone, Indapamide, Hydrochlorothiazide, Methyclothiazide, Metolazone Loop diuretics: • Inhibit Na+K+Cl2- cotransporter in thick ascending limb • Bumetanide, Furosemide, Ethacrynate, Torsemide, Piretanide Potassium sparing diuretics: • Inhibit Na+ reabsorption in the collecting duct • Amiloride, Spironolactone (Aldactone), Triamterene Carbonic anhydrase inhibitors: • Inhibit Na+ and HC03- in the proximal tubule • Acetazolamide, Methazolamide Osmotic diuretics: • Promote Na+ and water loss through the nephron by excretion of non-reabsorbable filtrate • Glycerin (Glycerol), Isosorbide, Mannitol, Urea Vasopressin receptor antagonists (also called Vaptans): • Aquaretics (not a diuretic as no effect on sodium reabsorption)-promote water excretion by inhibiting antidiuretic hormone (ADH)-mediated water reabsorption in the collecting duct Satyendra Dhar, MD @DharSaty #Diuretics #Pharmacology #nephrology #conversion #loop #thiazide #classes
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Satyendra Dhar, MD
@DharSaty
Hospital Medicine Clinical Assistant Professor The content and images on this website are provided for educational and informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. The views expressed are those of the authors and do not necessarily reflect those of any affiliated institutions. While efforts are made to ensure accuracy and currency, medical knowledge is continually evolving, and errors or omissions may occur. Users are advised to independently verify information and seek guidance from qualified healthcare professionals for any medical decisions. By using this website, you acknowledge responsibility for your own clinical judgments, and the website and its contributors disclaim any liability arising from the use of its content. 👉 Follow 'Medical Infographics' on 👉 https://www.DharSaty.com
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