Clopidogrel (Plavix) and Clopidogrel Non-responders



Clopidogrel is an irreversible selective inhibitor of the platelet low-sensitivity adenosine diphosphate receptor: P2Y12



Clopidogrel non-responders:

 • Most commonly implicated is a genetic polymorphism in CYP2C19 activity making the individual a poor or intermediate metabolizer of clopidogrel to its active metabolite

 • Another factor to consider is co-administration of strong CYP2C19 inhibitors - These include PPIs (most notably omeprazole), antifungals (most notably fluconazole), and fluoxetine



By Dr. Kathryn Watson @Kat_Watson



#Clopidogrel #Plavix #Nonresponders #pharmacology #toxicology