Approach to Leukocytosis - Differential Diagnosis Algorithm



Features of hematologic malignancy:

 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression

 • Exam: lymphadenopathy, petechiae, splenomegaly, hepatomegaly

 • Labs: anemia, ↑ MCV, ↑/↓ platelets, persistent WBC > 30k (or > 20k after initial Rx), basophilia, plasmacytosis, monomorphic lymphocytosis, predominant immature cells



Matthew Ho, MD PhD @MatthewHoMD

 

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