Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis



Neurologic-Centered:

 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia

 (-) Systemic Features: CANOMAD, DADS-M, Sporadic, late-onset nemaline myopathy



Cutaneous-centered:

 • Systemic capillary leak syndrome (Clarkson's)

 • Scleromyxedema & Necrobiotic xanthogranuloma (NXG)

 • POEMS & TEMPI

 • Schnitzler syndrome

 • Cryoglobulinemia



Renal-centered (ie "MGRS"):

 • Organized Ig deposits: Ig-related amyloid, Monoclonal immunotactoid GN, Type I cryo GN, Light-chain proximal tubulopathy

Non-organized Ig deposits: Ig deposition disease (light chain vs. heavy chain vs. both), Proliferative GN w/ monoclonal Ig deposits, C3 glomerulopathy w/ monoclonal gammopathy

• (-) Ig deposits: TMA w/ monoclonal gammopathy



Andrew Sanchez M.D. @ASanchez_PS



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