Pancytopenia - Differential Diagnosis Algorithm

 • 12-13 g/dL,

 • ANC < 1800/uL,

 • platelet < 150,000/uL



Initial Workup: CBC with diff, BMP, uric acid, peripheral smear, reticulocyte count, LFTs, LDH, ESR, CRP, iron studies, PT/aPTT



Differential Diagnosis:

 • ↓ Production (↓ reticulocytes, reticulated-plts)

 • ↑ Destruction + ↓ Production

 • ↑ Destruction (hemolysis, ↑ reticulocytes, reticulated-plts)

 • Splenic sequestration (splenomegaly)



Matthew Ho, MD PhD @MatthewHoMD



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