Macrolides - Erythromycin, Clarithromycin, Azithromycin - Antibiotics Class Overview
50S Ribosomal Inhibitor (PO and IV)
Spectrum: Atypical organisms (Chlamydia, Mycoplasma, Legionella), also some activity vs. Gram positive cocci and some gram negatives.
Used for: Azithromycin - low-risk bronchitis, COPD exacerbations, community-acquired pneumonia, sinusitis, Strep throat in PCN allergic patients, and more. Used in conjunction with Ceftriaxone for CAP that requires hospitalization. Used for MAC treatment (combination therapy) and for prophylaxis in HIV/AIDS patients with CD4 <50. Also used for STD Chlamydia.
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