Vancomycin and Dalbavancin (lipoglycopeptide antibiotics) - Antibiotics Class Overview


Mechanism: Glycopeptide -  inhibits cell wall synthesis in Gram positives (different protein than beta lactams – D-Ala-D-Ala).

Spectrum: gram positive agent with activity vs Staph (including MRSA), Strep, and nonVRE Enterococcus.  No gram negative coverage.   Considered the gold standard for MRSA infections. 


Used for:  all sorts of situations with suspected or proven gram positive infections from above organisms, including bacteremia, meningitis, PNA, skin/soft tissue, and more.  Drug of choice for gram positive infections in patients with severe beta-lactam allergy.


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