Daptomycin  - Antibiotics Class Overview


Mechanism: Lipopeptide antibiotic – forms transmembrane channels and depolarizes cells.  Rapidly cidal drug.   
Spectrum: only covers Gram positives including MRSA, strep, and Enterococcus/VRE.  No gram negative activity.
Used for: complicated skin/soft tissue infections, also being used more for MRSA bacteremia/endocarditis (due to cidal nature)
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