Pulmonary Complications Following Stem Cell Transplant


For patients in the pre- engraftment period (day 0-30):
 - 

Pulmonary infections
 - Pulmonary edema
 - Engraftment syndrome (typically within 10 days, more common with autologous transplant)
 - Diffuse alveolar hemorrhage (more common in allogenic than autologous)
 - Idiopathic pneumonia syndrome (more common in allo than auto)
 - Hyperacute/acute GVHD predominate.
 - TRALI/TACO due to transfusion support
For patients in the early post- engraftment period (Engraftment day-100 days post engraftment):

 - Infectious more likely (viral- influenza, CMV, adenovirus, bacterial- pneumococcus, legionella, nocardia,actinomyces,mycobacteria, and fungal- PCP, aspergillus)
 - Idiopathic pneumonia syndrome
 - Drug toxicity/Radiation pneumonitis

For patients in the post-engraftment period (day 100 onward):

 - Bronchiolitis obliterans
 - Organizing pneumonia
 - Malignancy
 - Pulmonary alveolar proteinosis/pulmonary cytolytic thrombi
 - Radiation pneumonitis
 - Autoimmune connective tissue disorders


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