Algorithm for the Diagnosis of Serotonin Syndrome

Algorithm for the Diagnosis of Serotonin Syndrome
 - Serotonin syndrome is thought to be caused by excess agonism of 5-HT2A Receptors
 - 60% of patients present within 6 hours of change or administration of medication leading to SS.
 - Clinical findings with a statistically significant association with SS include: hyperreflexia, inducible clonus, myoclonus, ocular clonus, spontaneous clonus, peripheral hypertonicity, and shivering.
 - Hyperreflexia, clonus, and rigidity are more prominent in the lower extremities in SS.
 - Serotonin syndrome must be distinguished from other toxindromes that present similarly: neuroleptic malignant syndrome, anticholinergic poisoning, and malignant hyperthermia
 - Most cases will resolve after 24 hours with initiation of treatment (see below) and discontinuation of the offending agent.

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Contributed by

Dr. Gerald Diaz
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: | Twitter:

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