Melanoma Pathogenesis

Environmental exposure (UV ...
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Description

Melanoma Pathogenesis


Environmental exposure (UV light) + genetic susceptibility (CDKN2A, CDK4, MC1R, BRAF, p16/ARF genes) → accumulation of genetic mutations in melanocyte that activate oncogenes, inactivate tumour suppressor genes and impair DNA repair → melanocyte proliferation, blood vessel growth, tumour invasion, evasion of immune response, metastasis.
#Pathophysiology #Oncology #Melanoma #Carcinogenesis
Contributed by

Dr. Gerald Diaz
@GeraldMD
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG:  https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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