Antibiotics for severe community-onset pneumonia 

Atypical ...

Antibiotics for severe community-onset pneumonia 

Atypical coverage always 

- Usually azithromycin 500 mg daily 

- Doxycycline if animal exposure or 

contraindication to azithromycin 

Beta-lactam backbone 

- Usually ceftriaxone (safe for non•anaphylactic penicillin allergy) 

Consider two grams IV daily esp. in heavier patients. 

- Risk for pseudomonas: cefepime or piperacillin-tazobactam 

Septic Shock

Structural lung disease (severe COPD, bronchiectasis, cystic fibrosis) 

Broad-spectrum antibiotics for >7 days in past month 

Hospitalization for > 1 day in last three months 

Immunocompromise (e.g. chemotherapy, steroid > I Omg/d) 

Nursing home resident with poor functional status 

- History of penicillin anaphylaxis: meropenem 

- Don't use ceftazidime (poor gram-positive coverage) 

MRSA coverage? 

only in selected cases 

- Linezolid 1 st line 600 mg ql 2hr 

- Vancomycin 

#Community #Acquired #Pneumonia #CAP #Antibiotics #Coverage #Management
Contributed by

Dr. Gerald Diaz
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: | Twitter:

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