FAT RBC Mnemonic for Causes of Macrocytic Anemia

(MCV > 100)



F - Folate (Fetus) and B12 Deficiency - Impairs DNA synthesis for RBC production

A - Alcohol - Direct bone marrow toxicity

T - Thyroid (Hypothyroidism)

R - Reticulocytosis - Larger, immature RBCs released from marrow as a response to anemia

B - Bone Marrow Disorders (MDS, leukemia)

C - Cirrhosis, Chemicals (drugs, chemotherapy) 



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