Amiodarone Toxicity and Monitoring



Tremor Ataxia 

Ocular neuritis 

Corneal Microdeposits 

Bradycardia 

Pulmonary fibrosis 

Hepatotoxicity 

Blue-gray skin  

Photosensitivity 

Hyperthyroid 

Hypothyroid 

Peripheral Neuropathy 



Pharmacokinetic Considerations 

 - Large Volume of Distribution 

 - Half life = 60 days  *delays onset and offset* 

 - Substrate CYP3A4 

 - Inhibitor of CYP2C9-3A4-2D6 and P-Glycoprotein 

 - Key DDI: digoxin, statins, warfarin, phenytoin, dabigatran 



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