Sepsis - Interventions that do / do not improve outcomes
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Sepsis - Interventions that do / do not improve outcomes


- Have high index of suspicion and understand those at risk 

- Take a history - understand confirmation and fixation bias - what is the likely source 

- Have a sepsis pathway or protocol 

- Have a rapid response team who know what they are doing 

- Give (not prescribe) antibiotics now if you think patient has bacterial sepsis 

- Talk to others - infectious disease specialists, surgeons, your team - especially your team 

- Pay nurses well, pay ICU doctors well - have enough of both 

- Consider corticosteroids for persistent septic shock 

- Understand late mortality 

- Enroll patient in a clinical trial 

Don't Know / Doesn't Matter:

- Immune stimulation 

- Vitamin C / Thiamine 

- Vasopressin vs. adrenaline vs. noradrenaline 

- Lots more 


- Fixate on magic bullets 

- Target normoglycemia 

- Target hypothermia 

- Do too much - ventilation, transfusion, fluid resuscitation, oxygen, CRRT, HFO 

- Give synthetic colloid - especially HES 

Dr. Steve Mathieu -

#Sepsis #Interventions #Management #Factors #Matter #EBM #Effectiveness #Improve #Outcomes #Evidence
Contributed by

Dr. Gerald Diaz
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: | Twitter:
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