CSF Penetration of Antimicrobials



Despite the poor CSF penetration, beta-lactams have the most research documenting successful treatment of community-acquired meningitis compared to other antibiotic classes.



1 only FDA-approved for UTI treatment

2 no studies have been published looking at CNS penetration; however has been used successfully in clinical CNS infections

3 overcome by increase in dosages – higher dosages of beta-lactams obtain adequate levels in the CSF and tend to be 1st line agents in bacterial meningitis due to their efficacy and bactericidal properties

4 however has been shown to effectively treat susceptible CNS infections

5 however clinical trials have shown good outcomes when used in treatment of CNS infections



- Dr. Milana Bogorodskaya https://twitter.com/foamid



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