Cerebral Toxoplasmosis 

- Most comrnon CNS infection in patients with AIDS 

who are not receiving appropriate prophylaxis 

Clinical 

 • Headache 

 • Fever 

 • Altered mental status 

 • Seizure 

Management 

First line 

 • Sulfadiazine and pyrimethamine 

 • Leucovorin (co-administer to prevent pyrimethamine-induced hematologic toxicity) 

Second line 

 • Clindamycin plus pyrimethamine plus leucovorin 

 • Atovaquone plus pyrimethamine plus leucovorin 

#Cerebral #Toxoplasmosis #Diagnosis #Overview #Management