Hemophagocytic Lymphohistiocytosis (HLH) Diagnostic Criteria - 2004 vs 2009



At least three of the following: 

 - Fever

 - Splenomegaly 

 - Cytopenia affecting at least two cell lines: 

    - Hemoglobin <9 g/L 

    - Platelets < 100 b/L 

    - Absolute neutrophil count < 1000 b/L 

 - Hepatitis 

At least one of the following: 

 - Ferritin elevation 

 - Elevated soluble CD25 (soluble IL2-receptor) 

 - Hemophagocytosis seen on tissue biopsy 

 - Low/absent NK-cell activity 

Other supportive features (not required) 

 - Hypertriglyceridemia 

 - Hypofibrinogenemia 

 - Hyponatremia 



Dr. Josh Farkas @PulmCrit



#HLH #Hemophagocytic #Lymphohistiocytosis #Diagnosis #Criteria #Hematology