Diagnosis of Cryoglobulinemia Vasculitis

1) Presence ...
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Description

Diagnosis of Cryoglobulinemia Vasculitis



1) Presence of cryoglobulin 

Circulating immunoglobulins that precipitate with cold temperature and dissolve with warming. Variable levels not related to clinical severity.  Cryoglobulins are characterized into 3 types 



2) Vasculitis with cryoglobulin immune deposits affecting small vessels (capillaries, venules, or arterioles) 

MONOCLONAL CRYOGLOBULINEMIA (type l) : Vascular occlusion >> vasculitis 

 • Raynaud phenomenon 

 • Ulcers, distal necrosis 

 • Pain and swelling in the extremities 

 • Hyperviscosity syndrome 

MIXED CRYOGLOBULINEMIA (types II and Ill) 

 • Vascular purpura +++ 

 • Peripheral neuropathy 

 • Arthralgia, arthritis 

 • Renal Involvement



Dr. Benjamin Terrier @ https://twitter.com/TerrierBen



#Cryoglobulinemia #Vasculitis #Diagnosis #Rheumatology #Cryoglobulinemic
Contributed by

Dr. Gerald Diaz
@GeraldMD
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG:  https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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