Fibrates - Gemfibrozil and Fenofibrate 
Mechanism: ...

Fibrates - Gemfibrozil and Fenofibrate 

Mechanism: activates PPAR alpha

Lipid Effects:

 - Decrease TG by 30-50%

 - Increase HDL by 5-15% 

 - Decrease LDL by 0-20% 

The Fibrate drug class includes gemfibrozil and fenofibrate. These 2 medications were very commonly used to treat dyslipidemia, specifically hypertriglyceridemia since it has great triglyceride lowering. It's very important to remember not to use either of these medications with a statin, as this increases the risk of rhabdomyolysis.

Jarred Prudencio, PharmD -

#Fibrates #Gemfibrozil #Fenofibrate #Pharmacology #LipidEffects
Contributed by

Dr. Gerald Diaz
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: | Twitter:

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