Fibrates - Gemfibrozil and Fenofibrate
Mechanism: activates PPAR alpha
- Decrease TG by 30-50%
- Increase HDL by 5-15%
- Decrease LDL by 0-20%
The Fibrate drug class includes gemfibrozil and fenofibrate. These 2 medications were very commonly used to treat dyslipidemia, specifically hypertriglyceridemia since it has great triglyceride lowering. It's very important to remember not to use either of these medications with a statin, as this increases the risk of rhabdomyolysis.
Jarred Prudencio, PharmD - https://www.instagram.com/ambcarerx
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