NSAID vs ACEI/ARB effects on the Kidneys



Remember that NSAIDs and ACEI/ARB therapy have opposing effects on the kidneys. NSAIDs cause vasoconstriction of the afferent (arriving) arteriole, which may contribute to kidney damage. In patients with normal kidney function, NSAID use shouldn't cause damage, it's more of a concern if patients have CKD or additional risk factors. ACEI/ARB's are often used for their kidney protective benefits, since they dilate the efferent (exiting) arteriole.



Jarred Prudencio, PharmD - https://www.instagram.com/ambcarerx



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