Fibrinolysis occurs when plasminogen is activated to plasmin under the influence of factors such as kallikrein (a peptidase). urokinase, and tissue plasminogen activator (t-PA). Plasmin then acts on the fibrin meshwork to dissolve the clot into fibrinopeptides. Streptokinase and urokinase act as thrornbolytic drugs by activating plasminogen. Some anticoagulant drugs (e.g., tranexamic acid), as well as endogenous substances (a2-antiplasmin), act by inhibiting plasma-mediated fibrinolysis.
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