Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease

Increased Thrombosis 

Increased Platelet-Vesset Wall Interaction 

 • Incr von Willebrand factor 

 • Incr ADAMTS 13 

High Thrombin Generation 

 • Incr Factor VIII 

 • Decr Protein C, Protein S 

 • Decr Antithrombin 

 • Decr TFPI

Low Fibrinolysis 

• Decr Plasminogen 

• Incr  PAI 



#Thrombosis #Bleeding #Clot #Cirrhosis #Pathophysiology #Hepatology #Liver