Carbamazepine Toxicity



Carbamazepine (CBZ) is an antiepileptic drug commonly prescribed for seizure disorders, trigeminal neuralgia, neuropathic pain, schizophrenia & bipolar disorder



Its mechanism of action involves:

 - Antagonism of inactivated voltage-dependent Na+ channels

 - Antagonism of L-type voltage-gated Ca+2 channels

 - Adenosine receptor agonism (at therapeutic doses) & antagonism (at toxic doses)

 - Anticholinergic properties (antimuscarinic)

 - Serotonin reuptake inhibition

 - Inhibition of glutamate neurotransmission



By Dr. Kathryn Watson @Kat_Watson



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