When to look for clonal/neoplastic hypereosinophilia (HEo)?

 - Exclusion of frequent causes (Drug-induced HEo, helminthiasis, cancer, ...)

 - Clinical symptoms (Male gender, Splenomegaly)

 - Hemogram abnormalities (Cytopenia, Other cell proliferation, monocytosis)

 - Myelogram/BM biopsy (Mast cells (FIP1L1), Myelofibrosis, Blastosis)

 - Incr Cobalamin, Incr Tryptase

 - Resistance to glucocorticoids



By Dr. Julien Rohmer via Dr. Benjamin Terrier @TerrierBen



#Neoplastic #hypereosinophilia #HEON #Diagnosis #Signs #Hematology #Workup