Uric Acid Homeostasis
In the liver, purines are metabolized to uric acid. The last step in purine metabolism involves an enzyme called xanthine oxidase. In animals, the enzyme uricase converts uric acid to allantoin, a highly soluble compound.
Uricase is not present in humans. The gout drug pegloticase (Krystexxa) is a recombinant version of uricase.
The intestines eliminate about 1/3 of the daily uric acid produced
The kidneys eliminate about 2/3 of the daily uric acid produced. Uric acid is freely filtered in the glomerulus and 90% is reabsorbed in the proximal tubule.
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