Uric Acid Homeostasis
In the liver, purines are metabolized ...
1.2K
Description

Uric Acid Homeostasis

In the liver, purines are metabolized to uric acid. The last step in purine metabolism involves an enzyme called xanthine oxidase. In animals, the enzyme uricase converts uric acid to allantoin, a highly soluble compound. 

 Uricase is not present in humans. The gout drug pegloticase (Krystexxa) is a recombinant version of uricase.



The intestines eliminate about 1/3 of the daily uric acid produced

The kidneys eliminate about 2/3 of the daily uric acid produced. Uric acid is freely filtered in the glomerulus and 90% is reabsorbed in the proximal tubule.



#UricAcid #Homeostasis #Gout #Pathophysiology #Pharmacology #Medications #Management
Contributed by

Dr. Gerald Diaz
@GeraldMD
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG:  https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
0 Comments

Related content