Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia 



DIAGNOSTIC CRITERIA FOR ICL

 • Persistent CD4 T-cell lymphopenia

 • NO underlying primary or secondary immune deficiencies

 • CD4 T-cell count of 300 cells/mL or 20% total lymphocyte on multiple occasions

COMMON ASSOCIATIONS W/ LOW CD4

 • Autoimmune (Sjogren, SLE, Kikuchi dz.)

 • Drugs (corticosteroids. chemotherapy)

 • Genetic syndromes (XMEN. WHIM. Unc119)

 • Heme (lymphoma. aplasia/myelodysplasia)

 • Infections - HIV. HTLV. EBV. CMV. MTB/MAC

 • Common variable immune deficiency

 • Sarcoidosis

 • Radiation therapy



Dr. Kushal Vaishnani @k_vaishnani



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