Indications for Serum Protein Electrophoresis (SPEP)

Indications for Serum Protein Electrophoresis (SPEP)

 • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related disorder

 • Unexplained peripheral neuropathy (not attributed to longstanding diabetes mellitus, toxin exposure, chemotherapy, etc.)

 • New-onset anemia associated with renal failure or insufficiency and bone pain

 • Back pain in which multiple myeloma is suspected

 • Hypercalcemia attributed to possible malignancy (e.g., associated weight loss, fatigue, bone pain, abnormal bleeding)

 • Rouleaux formations noted on peripheral blood smear

 • Renal insufficiency with associated serum protein elevation

 • Unexplained pathologic fracture or lyric lesion identified on radiograph

 • Bence Jones proteinuria

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Contributed by

Dr. Gerald Diaz
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: | Twitter:

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