Diuretics and Agents Regulating Renal Excretion

Carbonic ...
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Description

Diuretics and Agents Regulating Renal Excretion



Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)

 • Glaucoma

 • Epilepsy

 • Altitude sickness

 • Diuretic resistance

 • Metabolic alkalosis

 • Familial periodic paralysis

Osmotic Diuretics (Mannitol)

 • Elevated intraocular pressure

 • Elevated intracranial pressure

 • Dialysis disequilibrium syndrome

 • Diagnosis of bronchial hyperreactivity

 • Urologic irrigation

 • Management of some overdoses

Inhibitors of Na+K+2Cl- Symport (Loop Diuretics; High-Ceiling Diuretics) (Bumetanide, Ethacrynic acid, Furosemide, Torsemide)

 • Acute pulmonary edema

 • Edema associated with congestive heart failure, liver cirrhosis, chronic kidney disease, and nephrotic syndrome

 • Hyponatremia

 • Hypercalcemia

 • Hypertension

Inhibitors of Na+CI- Symport - Thiazide Diuretics (Chlorothiazide, Hydrochlorothiazide, Methyclothiazide, Chlorthalidone, Indapamide, Metolazone)

 • Hypertension

 • Edema associated with congestive heart failure, liver cirrhosis, chronic kidney disease, and nephrotic syndrome

 • Nephrogenic diabetes insipidus

 • Kidney stones caused by Ca2+ crystals

Inhibitors of Renal Epithelial Channels (K+ Sparing Diuretics) - Amiloride, Triamterene

 • Hypertension

 • Edema associated with congestive heart failure, liver cirrhosis, and chronic kidney disease

 • Liddle syndrome

 • Lithium-induced nephrogenic diabetes insipidus

Mineralocorticoid Receptor Antagonists (Aldosterone Antagonists, K+ Sparing Diuretics) (Eplerenone, Spironolactone)

 • Hypertension

 • Edema associated with congestive heart failure, liver cirrhosis, chronic kidney disease

 • Primary hyperaldosteronism

 • Acute myocardial infarction (eplerenone)

 • Heart failure (in combination with standard therapy)

 • Polycystic ovary disease

Inhibitors of the Nonspecific Cation Channel (Naturietic Peptide Analogues) - Nesiritide

 • Hospitalized patients with acutely decompensated congestive heart failure (New York Heart Association class IV)

Vasopressin Receptor Agonist

V1 receptor-agonist (Vasopressin)

 • Postoperative abdominal distention

 • Abdominal roentgenography

 • Bleeding

 • Cardiac arrest

 • Hypovolemic shock

V2 receptor-agonist - Desmopressin (DDAVP)

 • Central diabetes insipidus

 • Primary nocturnal enuresis

 • Prevention of blood loss in patients with specific bleeding disorders

Vasopressin Receptor Antagonists (Conivaptan, Tolvaptan)

 • Treatment of hypervolemic and euvolemic hyponatremia



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