Factor VIII synthesis - Normal, Haemophilia A and Von ...
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Factor VIII synthesis - Normal, Haemophilia A and Von Willebrand Disease



Normal - vWF carrier protein protects VIII:C from degradation. It is released by activated thrombin.

Haemophilia A - Defective synthesis of VIII:C

Von Willebrand Disease - Rapid degradation of VIII:C in the absence of vWF.



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