Drugs for Depression and Anxiety Disorders



Selective Serotonin Reuptake Inhibitors

 • Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone

 • Anxiety and depression disorders

 • Obsessive-compulsive disorder, PTSD

 • SERT selective; little effect on NET

 • Vilazodone also acts as 5HTIA partial agonist

Serotonin-Norepinephrine Reuptake Inhibitors

 • Venlafaxine, Desvenlafaxine, Duloxetine, Milnacipran, Levomilnacipran

 • Anxiety and depression, ADHD, autism, fibromyalgia, PTSD, menopause symptoms

 • Inhibitors of SERT and NET

Tricyclic Antidepressants

Amitriptyline, Clomipramine, Doxepin, Imipramine, Trimipramine, Nortriptyline, Maprotiline, Protriptyline, Desipramine, Amoxapine

 • Block SERT, NET, a1, H1 and M1 receptors

 • Major depression

Atypical Antipsychotics

 • Aripiprazole, Brexpiprazole, Lurasidone, Olanzapine, Quetiapine, Risperidone

 • Resistant major depression and psychotic disorders

 • Schizophrenia

 • Bipolar depression

Monoamine Oxidase Inhibitors

 • Isocarboxazid, Phenelzine, Selegiline, Tranylcypromine

 • Inhibit MAOA and MAOB to prevent NE, DA, and 5HT breakdown

 • Major depression disorders resistant to other antidepressants

Atypical Antidepressants

 • Bupropion, Trazodone, Nefazodone, Mirtazapine, Mianserin, Vortioxetine

 • Depression

 • Smoking cessation (bupropion)

 • Insomnia (low-dose trazodone)



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