ANCA-Associated Vasculitis
A group of necrotizing, ...
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Description

ANCA-Associated Vasculitis

A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due to the lack of immune deposits. Includes granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulonatosis with polyangiitis (EGPA).

 - C-ANCA pattern (usually associated with PR3+ antibody)

 - P-ANCA pattern (usually associated with MPO+ antibody)



Granulomatosis with polyangiitis - 80-90% PR3+

Granulomatosis with polyangiitis without renal involvement - PR3>MPO

Microscopic polyangiitis - MPO>PR3

Eosinophilic granulomatosis with polyangiitis - MPO>PR3

Renal-limited - MPO+ about 75-90%, rarely PR3

Anti-GBM disease - MPO>PR3

Levamisole-induced vasculitis - MPO+ almost 100%, PR3+ 50%, frequently double+

Hydralazine-induced ANCA vasculitis - MPO > PR3



Dr. Ann Marie Kumfer @AnnKumfer



#ANCA #Associated #Vasculitis #CANCA #PANCA #MPO #PR3 #Diagnosis #Rheumatology
Contributed by

Dr. Gerald Diaz
@GeraldMD
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG:  https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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